【4565】そーせいG 437 【第3四半期決算発表2月14日予定】

[過去ﾛｸﾞ] 【4565】そーせいG 437 【第3四半期決算発表2月14日予定】 (812ﾚｽ)
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810: (ﾜｯﾁｮｲ b78e-K9Vl) 2018/02/20(火)17:30 ID:RAsWa/Kl0(11/12) AA×

810:  (ﾜｯﾁｮｲ b78e-K9Vl) [] 2018/02/20(火) 17:30:09.30 ID:RAsWa/Kl0

※BioRxiv: New Results: "Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein": Christopher G Tate.
・Posted February 19, 2018.
Abstract
The adenosine A2A receptor (A2AR) is a prototypical G protein-coupled receptor (GPCR) that couples to the heterotrimeric G protein GS.
Here we determine the structure by electron cryo-microscopy (cryo-EM) of A2AR at pH 7.5 bound to the small molecule agonist NECA and coupled to an engineered heterotrimeric G protein, which contains mini-GS, the bg subunits and nanobody Nb35.
Most regions of the complex have a resolution of ~3.8 &#197; or better. Comparison with the 3.4 &#197; resolution crystal structure shows that the receptor and mini-GS are virtually identical and that the density of the side chains and ligand are of comparable quality.
However, the cryo-EM density map also indicates regions that are flexible in comparison to the crystal structures, which unexpectedly includes regions in the ligand binding pocket.
In addition, an interaction between intracellular loop 1 of the receptor and the b subunit of the G protein was observed.

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