[過去ﾛｸﾞ] 【4565】そーせいG 437 【第3四半期決算発表2月14日予定】 (812ﾚｽ)
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806: (ﾜｯﾁｮｲ b78e-K9Vl) 2018/02/20(火)17:01 ID:RAsWa/Kl0(9/12) AAS
12/_8 (終値10100) 売残高__900 買残高 1849800 ・(12/6安値_9970)
12/15 (終値10870) 売残高__900 買残高 1763800 ・(12/11安値10070)
12/22 (終値10550) 売残高__300 買残高 1724500 ・(12/22安値10530)
12/29 (終値10940) 売残高__300 買残高 1634900 ・(12/26安値10330)
_1/12 (終値11700) 売残高_3400 買残高 1507400 ・(1/5安値10530)
_1/19 (終値10870) 売残高__300 買残高 1643700 ・(1/19安値10800)
_1/26 (終値12210) 売残高__900 買残高 1429100(-214600) ・(1/22安値10960)※[振るいも順調に推移]
_2/_2 (終値11650) 売残高__300 買残高 1482300(_+53200) ・(1/31安値11440)
_2/_9 (終値10330) 売残高12500 買残高 1524700(_+42400) ・(2/6安値_9700)
_2/16 (終値_9920) 売残高11800 買残高 1591200(_+66500)※2/20up ・(2/14安値_9700)
省2
807: (ﾜｯﾁｮｲ b78e-K9Vl) 2018/02/20(火)17:01 ID:RAsWa/Kl0(10/12) AAS
※Technical Analysis Charts (Week)：
外部ﾘﾝｸ[aspx]:www.zonebourse.com
更なる成長の黎明期、上抜け圏にて、強気相場解除後の時間軸での調整(振るい)は順調に推移してますね。笑。
時間軸調整終盤、今回も拾い場を経て、予定通りに推移し、振るいも面白くなりました。笑。
成長戦略の進捗と共に、次なる展開・進捗が楽しみです。笑。
808(1): (ﾜｯﾁｮｲWW 576f-n5UA) 2018/02/20(火)17:08 ID:30WFBzhG0(1) AAS
こら買われんわw
809: (ｽﾌﾟﾌﾟ Sdbf-ZOQc) 2018/02/20(火)17:24 ID:i0B+IFb7d(3/3) AAS
>>808
スレがある事でバレてる
もう売るだけの奴らだけ集まって頭悪い所や悪口見てたら誰も買わない
分かってない
とにかくスレを消せ！せめて隠せ
810: (ﾜｯﾁｮｲ b78e-K9Vl) 2018/02/20(火)17:30 ID:RAsWa/Kl0(11/12) AAS
※BioRxiv: New Results: "Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein": Christopher G Tate.
・Posted February 19, 2018.
Abstract
The adenosine A2A receptor (A2AR) is a prototypical G protein-coupled receptor (GPCR) that couples to the heterotrimeric G protein GS.
Here we determine the structure by electron cryo-microscopy (cryo-EM) of A2AR at pH 7.5 bound to the small molecule agonist NECA and coupled to an engineered heterotrimeric G protein, which contains mini-GS, the bg subunits and nanobody Nb35.
Most regions of the complex have a resolution of ~3.8 Å or better. Comparison with the 3.4 Å resolution crystal structure shows that the receptor and mini-GS are virtually identical and that the density of the side chains and ligand are of comparable quality.
However, the cryo-EM density map also indicates regions that are flexible in comparison to the crystal structures, which unexpectedly includes regions in the ligand binding pocket.
In addition, an interaction between intracellular loop 1 of the receptor and the b subunit of the G protein was observed.
811: (ﾜｯﾁｮｲ b78e-K9Vl) 2018/02/20(火)17:35 ID:RAsWa/Kl0(12/12) AAS
Acknowledgements:
・This work was funded by a grant from the European Research Council (EMPSI 339995) Heptares Therapeutics Ltd, Pfizer and core funding from the Medical Research Council [MRC U105197215].
・We thank Rishi Matadeen and Kasim Sader for their help with cryo EM data collection, Christos Savva for his help in using the VPP and Wim Hagen for the SerialEM single-particle data collection script.
・We also thank Rafael Fernandez-Leiro, Sjors Scheres and Paula da Fonseca for useful discussions.
Competing financial interests:
・CGT is a consultant and shareholder of Heptares Therapeutics, and they also funded this work.
812: (ｱｳｱｳｶｰ Sa6b-QRmp) 2018/02/20(火)19:31 ID:kRSnhjDYa(1) AAS
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